BIOWEB: MOLECULAR MODELING GROUP

bioweb: molecular modeling group / grupo de modelado molecular

[ http://bioweb.cbm.uam.es ] [ http://www.cbm.csic.es/bioweb ]

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Paulino Gómez-Puertas

Dr. Paulino Gómez-Puertas.
(Sta. Mª del Páramo, León -Spain-. 1965)
Research Scientist CSIC / Científico Titular CSIC.
Associated Researcher IdiPAZ / Investigador Asociado IdiPAZ.

Centro de Biología Molecular Severo Ochoa.
C/ Nicolás Cabrera, 1.
Campus UAM. Cantoblanco, 28049 Madrid. Spain.
Tel: (+34) 91-196-4663 Fax: (+34) 91-196-4420

e-mail: pagomez@cbm.csic.es

URL: http://bioweb.cbm.uam.es / http://www.cbm.csic.es/bioweb

Academic degrees / Títulos académicos

Career / Trayectoria profesional.

since 2002

"Conexión Cáncer"

"Computational Biology and Bioinformatics"

"Biología Computacional y Bioinformática"

Awards & Scientific Societies / Reconocimientos y Sociedades Científicas.

1992. Doctorate Prize / Premio Extraordinario de Doctorado. Universidad Autónoma de Madrid.
1992. Member of the Spanish Society for Biochemistry and Molecular Biology / Miembro de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM).
1994. "Juan Abelló" Biochemistry Award / Premio "Juan Abelló" de Bioquímica. Spanish Royal Academy of Doctors / Real Academia de Doctores.
2013. Member of the Spanish Association of Human Genetics / Miembro de la Asociación Española de Genética Humana (AEGH).

Journals / Revistas.

Executive editor of "International Journal of Biological Macromolecules" / Editor ejecutivo del "International Journal of Biological Macromolecules".
Editorial board member of "International Journal of Molecular Sciences", sections "Molecular Biology" and "Molecular Biophysics" / Miembro del equipo editorial del "International Journal of Molecular Sciences", secciones "Molecular Biology" y "Molecular Biophysics".
Editorial Board Member of "Biophysica" / Miembro del equipo editorial de "Biophysica"
Referee for International Journals in the fields of Bioinformatics and Molecular Biology. / Revisor de Revistas Internacionales en los campos de la Bioinformática y la Biología Molecular.

Project evaluation / Evaluación de proyectos.

"National Evaluation and Foresight Agency (ANEP)" of the Spanish Ministry of Science and Innovation.
"Agency for Administration of University and Research Grants" of the Catalonian Autonomous Government.
"Administration Office for Research, Development and Innovation" of the Autonomous Government of Galicia.
"Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT)" of Argentina.
"Comisión Sectorial de Investigación Científica (CSIC-Uruguay)" of Uruguay.
"National Evaluation and Foresight Commission (FONCECYT-CONICYT)" of Chile.
Research and Development Administration Office of the University of Macau (Macau Special Administrative Region of the People's Republic of China).

Science policy and committees / Política científica y comisiones.

2006. Member of the Comission for Informatics - CBM. / Vocal de la Comisión de Informática - CBM.
2023. Participation in the "Science4Policy" initiative of the Consejo Superior de Investigaciones Científicas - CSIC. Report "Bacterial resistance to antibiotics". / Participación en la iniciativa "Science4Policy" del Consejo Superior de Investigaciones Científicas - CSIC. Informe "La resistencia de las bacterias a los antibióticos".
2023. Member of the Commission for Bioinformatics - CBM. / Vocal de la Comisión de Bioinformática - CBM.

Technology transfer / Transferencia de tecnología

2007. Founder of Biomol-Informatics SL, a spin-off company of Parque Científico de Madrid. / Fundador de Biomol-Informatics SL, una empresa "spin-off" del Parque Científico de Madrid.
2009. Biomol-Informatics participates in the "Divinocell" consortium, a Collaborative Project financed by the 7FP-EU (ref. HEALTH-F3-2009-223431) / Biomol-Informatics participa en el consorcio "Divinocell" un Collaborative Project financiado por el 7PM-UE (ref. HEALTH-F3-2009-223431). SEE AN INTERVIEW HERE / VEA UNA ENTREVISTA AQUÍ.
2011. Biomol-Informatics coordinates the "DIGEN-1K" consortium (participants: Madrid Science Park, IdiPaz, CSIC) financed by the Spanish Plan Nacional I+D+I 2011 (Ref: IPT-2011-0964-900000) / Biomol-Informatics coordina el consorcio "DIGEN-1K" (participantes: Parque Científico de Madrid, IdiPaz, CSIC) financiado por el Plan Nacional I+D+I 2011 (Ref: IPT-2011-0964-900000).
2012. Biomol-Informatics participates in the "Dorian" consortium, a Collaborative Project financed by the 7FP-EU (ref. FP7-HEALTH-2011-278603) / Biomol-Informatics participa en el consorcio "Dorian" un Collaborative Project financiado por el 7PM-UE (ref. FP7-HEALTH-2011-278603).
2012. Biomol-Informatics participates in the "Epi-TRAITS" consortium, a FP7 Marie Curie International Training Network (ref. FP7-PEOPLE-2012-ITN-316965) / Biomol-Informatics participa en el consorcio "Epi-TRAITS" un Proyecto Marie Curie - International Training Network - FP7 (ref. FP7-PEOPLE-2012-ITN-316965).
2014. Biomol-Informatics participates in the "IMI-ENABLE" consortium, a Innovatives Medicines Initiative within IMI’s New Drugs for Bad Bugs (ND4BB) programme (ref. IMI-DB4BB-ENABLE-115583) / Biomol-Informatics participa en el consorcio "IMI-ENABLE", en el marco de la "Innovatives Medicines Initiative" dentro del programa "New Drugs for Bad Bugs (ND4BB)" (ref. IMI-DB4BB-ENABLE-115583).
2022. PATENT
- "MiniACE2 proteins to block SARS-CoV2 infection". 2022. Patent no: NC2022/0005322. Patent in collaboration with the Instituto Distrital de Ciencia, Biotecnología e Innovación en Salud (IDCBIS) of Bogotá, Colombia.

Research projects / Proyectos de investigación

2002-2005. "Bio-PARTNeR: Protein interaction network". Fundación Ramón Areces. (Principal Inv: Paulino Gómez-Puertas).
2003-2004. "GenomeSpace: Sequence to structure". Intramural CAB. (Principal Inv: Paulino Gómez-Puertas).
2004. "Molecular basis of the anti-obesity properties of C75 compound". Fundacion Puleva. Research Prize 2004. (Principal Inv: Fausto G. Hegardt, Univ. Barcelona).
2004-2007. "Bioinformatics: Protein-protein and protein-ligand interactions. Modeling human CPTI function". Plan Nacional I+D+I. Ref: SAF2004-06843. (Coord: Fausto G. Hegardt, Univ. Barcelona; Principal Inv: Paulino Gómez-Puertas).
2006-2012. "Bioinformatics: Structure and function of human CPTI". F.I.S. CIBER 2006: Fisiopatología de la Obesidad y Nutrición. Ref: CB06/03/0026. (Inv. Principal: Fausto G. Hegardt, Univ. Barcelona).
2007-2009. "BIOSINCEL. Synthetic biology of cellular division: reconstruction of the bacterial division proto-ring". CSIC: Proyectos Intramurales de Frontera 2006. Ref: 200620F0022. (Coord: Miguel Vicente, CNB-CSIC; Principal Inv: Paulino Gómez-Puertas).
2007-2010. "COMBACT-CM. New targets to combat pathogenic bacteria". Comunidad de Madrid, I+D Biociencias 2006. Ref: S-BIO-0260-2006. (Coord: Miguel Vicente, CNB-CSIC; Principal Inv: Paulino Gómez-Puertas).
2008-2012. "Molecular bases of action of carnitine palmitoyltransferases as regulators of fat oxidation and their role on insulin resistance, type II diabetes and the hypothalamic appetite regulation". Plan Nacional I+D+I 2007. Eje-C Consolider. Ref: SAF2007-61926. (Coord. Consolider: Fausto G. Hegardt, Univ. Barcelona).
2009-2012. "DIVINOCELL. Exploiting Gram-negative cell division targets in the test tube to obtain antimicrobial compounds". FP7 collaborative project FP7-HEALTH-F3-2009-223431. (Biomol-Informatics).
2011-2014. "DORIAN. Developmental origins of healthy and unhealthy ageing: the role of maternal obesity". FP7 collaborative project FP7-HEALTH-2011-278603. (Biomol-Informatics).
2011-2012. "Use of specific peptides from proteins FtsA and FtsZ as antimicrobials". Plan Nacional I+D+I Ref.: EXPLORA SAF2011-13156-E. (Principal Inv.: Paulino Gómez-Puertas).
2011-2014. "DIGEN-1K: Experimental development of a Genetic Diagnostics Method using Next Generation Sequencing". Plan Nacional I+D+I Ref.: INNPACTO IPT-2011-0964-900000. (Principal Inv.: Paulino Gómez-Puertas).
2018-2021. "COMPUDRUG: Development of a new and efficient drug design system based on computational dynamic calculation of macromolecular structures". State Research Agency - Ref: RTC-2017-6494-1. (Principal Inv.: Paulino Gómez-Puertas).
2018-2020. "CONNECT: inCreasing cOmmunicatioN, awareNEss and data sharing in a global approaCh against resisTance". JPIAMR Virtual Research Institute Network. (Coord: Dr. Nicola Petrosillo, INMI-Rome; Principal Inv.: Paulino Gómez-Puertas).
2019-2022. "DRUGCOHESIN: New drugs for chromosome biology. Design of specific inhibitors of the Cohesin complex". State Research Agency - Ref: RTI2018-094434-B-I00. (Principal Inv.: Paulino Gómez-Puertas).
2020-2023. "EPIC Alliance: Alliance for the Exploration of Pipelines for Inhibitors of Carbapenemases". Joint Programming Initiative On Antimicrobial Resistance - JPIAMR Network Plus 2020. (Coord: Dr. Elias Dahdouh, IdiPAZ-Madrid; Principal Inv.: Paulino Gómez-Puertas).
2021-2023. "Combating Antibiotic-Resistant Enterobacteriaceae (CARE): structure-based discovery of clinical trial-ready inhibitors". Carlos III Health Institute - Ref: DTS20-00024. (Principal Inv.: Paulino Gómez-Puertas).
2022-2025. "New drugs to inhibit Carbapenemases. Discovery of compounds by structural design (DrugCarbapenem)". State Research Agency - Ref: PID2021-126625OB-I00. (Principal Inv.: Paulino Gómez-Puertas).

R&D contracts / Contratos de I+D.

2008-2017. Contract for Research and Development on Bioinformatics between Biomol-Informatics SL and Fundación Severo Ochoa. / Contrato de Investigación y Desarrollo en Bioinformática entre Biomol-Informatics SL y la Fundación Severo Ochoa. (Coordinador: Paulino Gómez-Puertas).

Ranking in publication indexes / Clasificación en índices de publicaciones

Web of Science h-index: 42; Scopus h-index: 41; Research.com D-index: 47, ResearchGate h-index: 48; Google Scholar i10-index: 108. (Sep. 2024)
Ranking of the world best Biology and Biochemistry scientists published in 2024 by Research.com: [ World #17516 & National #377 ]

Publications / Publicaciones [ PubMed ] [ Google Scholar ] [ ResearchGate ] [ Scopus ID 6701710022 ] [ ORCID 0000-0003-3131-729X ]
(A: article/artículo; R: review/revisión; C: book chapter/capítulo de libro; O: other/otros)

2024:

144(A).-	Arévalo-Romero, J.A., López-Cantillo, G., Moreno-Jiménez, S., Marcos-Alcalde, I., Ros-Pardo, D., Camacho-Rodríguez, B., Gómez-Puertas, P. & Ramírez-Segura, C.A. (Corresponding authors). (2024). In-silico design of miniACE2 decoys with in-vitro enhanced neutralization activity against SARS-CoV-2, encompassing Omicron Subvariants. International Journal of Molecular Sciences* 25, 10802. [PubMed] [PDF] [https://doi.org/10.3390/ijms251910802]
143(A).-	Ros-Pardo, D., Gómez-Puertas, P. & Marcos-Alcalde, I. (Corresponding author). (2024). STAG2-RAD21 Complex: a Unidirectional DNA Ratchet Mechanism in Loop Extrusion. International Journal of Biological Macromolecules 276, 133822. [PubMed] [PDF] [https://doi.org/10.1016/j.ijbiomac.2024.133822] [Supplementary Movie 1] [Supplementary Movie 2]
142(A).-	Escrig, J., Marcos-Alcalde, I., Domínguez-Zotes, S., Abia, D., Gómez-Puertas, P., Valbuena, A. & Mauricio G.Mateu, M. (2024). Structural Basis for Alternative Self-Assembly Pathways Leading to Different Human Immunodeficiency Virus Capsid-Like Nanoparticles. ACS Nano, in press. [PubMed] [PDF, in press] [https://doi.org/10.1021/acsnano.4c07948 ]
141(A).-	Furia, F., Levy, A.M.,..., Marcos-Alcalde, I., ..., Ros-Pardo, D., ..., Gómez-Puertas, P., Chung, W.K., Gardella, E. & Tümer, Z. (2024). The phenotypic and genotypic spectrum of individuals with mono- or biallelic ANK3 variants. Clinical Genetics 106, 574. [PubMed] [PDF] [https://doi.org/10.1111/cge.14587]
140(A).-	Campos-Díaz, A., Morejón-García, P., Monte-Serrano, E., Ros-Pardo, D., Marcos-Alcalde, I., Gómez-Puertas, P. & Lazo, P.A. (2024). Pathogenic effects of L200P and R387H VRK1 variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy. Journal of Molecular Medicine 102, 801. [PubMed] [PDF] [https://doi.org/10.1007/s00109-024-02442-8]
139(A).-	Ros-Pardo, D., Gómez-Puertas, P. & Marcos-Alcalde, I. (Corresponding author). (2024). STAG2: Computational Analysis of Missense Variants Involved in Disease. International Journal of Molecular Sciences 25, 1280. [PubMed] [PDF] [https://doi.org/10.3390/ijms25021280]

2023:

138(A).-

Colomo, S., Ros-Pardo, D., Oltra, S.S., Gómez-Puertas, P., Sarrió, D. & Moreno-Bueno G. (2023). Structural and functional insights into GSDMB isoforms complex roles in pathogenesis. Cell Cycle 22, 2346. [PubMed] [PDF] [https://doi.org/10.1080/15384101.2023.2287933]

137(A).-

Oltra, S.S., Colomo, S., Sin, L., Pérez-López, M., Lázaro, S., Molina-Crespo, A., Choi, K-H., Ros-Pardo, D., Martínez, L., Morales, S., González-Páramos, C., Orantes, A., Soriano, M., Hérnandez, A., Lluch, A., Rojo, F., Albanell, J., Gómez-Puertas, P., Ko, J-K., Sarrió, D. & Moreno-Bueno G. (2023). Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells. Cell Death and Differentiation 30, 1366–1381. [PubMed] [PDF] [https://doi.org/10.1038/s41418-023-01143-y]

2022:

136(R).-	Arnedo, M., Ascaso, A., Latorre-Pellicer, A., Lucía-Campos, C., Gil-Salvador, M., Ayerza-Casas, A., Pablo, M.J., Gómez-Puertas, P., Ramos, F.J., Bueno-Lozano, G., Pié, J. & Puisac, B. (2022). Molecular Basis of the Schuurs–Hoeijmakers Syndrome: What We Know about the Gene and the PACS-1 Protein and Novel Therapeutic Approaches. International Journal of Molecular Sciences 23, 9649. [PubMed] [PDF] [https://doi.org/10.3390/ijms23179649]
135(A).-	Lucía-Campos, C., Valenzuela, I., Latorre-Pellicer, A., Ros-Pardo, D., Gil-Salvador, M., Arnedo, M., Puisac, B., Castells, N., Plaja, A., Tenes, A., Cuscó, I., Trujillano, L., Ramos, F.J., Tizzano, E.F., Gómez-Puertas, P. & Pié, J. (2022). A novel intragenic duplication in HDAC8 gene underlying a case of Cornelia de Lange syndrome. Genes 13, 1413. [PubMed] [PDF] [https://doi.org/10.3390/genes13081413]
134(O).-	Dahdouh, E., Allander, L., Falgenhauer, L., Iorga, B.I., Lorenzetti, S., Marcos-Alcalde, I., Martin, N.I., Martínez-Martínez, L., Mingorance, J., Naas, T., Rubin, J.E., Spyrakis, F., Tängdén, T., & Gómez-Puertas, P. (2022). Computational Modeling and Design of new Inhibitors of Carbapenemases. A discussion from the EPIC Alliance network. International Journal of Molecular Sciences 23, 9746. [PubMed] [PDF] [https://doi.org/10.3390/ijms23179746]
133(A).-	Christensen, M.B., ..., Ros-Pardo, D., ..., Gómez-Puertas, P., Moller, R.S. & Tümer, Z. (2022). Biallelic variants in ZNF142 lead to a syndromic neurodevelopmental disorder. Clinical Genetics 102, 98-109. [PubMed] [PDF] [https://doi.org/10.1111/cge.14165]
132(R).-	Levy, A.M., Gómez-Puertas, P. & Tümer, Z. (Co-last authors). (2022). Neurodevelopmental disorders associated with PSD-95 and its 2 interaction partners. International Journal of Molecular Sciences* 23, 4390. [PubMed] [PDF] [https://doi.org/10.3390/ijms23084390]
131(A).-	Fernández-Justel, D., Marcos-Alcalde, I., Abascal, F., Vidaña, N., Gómez-Puertas, P., Revuelta, J.L. & Buey, R.M. (2022). Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase. Protein Science 31, e4314. [PubMed] [PDF] [https://doi.org/10.1002/pro.4314]
130(A).-	Kumble, S., ..., Gómez-Puertas, P., ..., Marcos-Alcalde, I., ..., Tümer, Z. (2022). The clinical and molecular spectrum of QRICH1 associated neurodevelopmental disorder. Human Mutation 43, 266–282. [PubMed] [PDF] [https://doi.org/10.1002/humu.24308]

2021:

129(A).-	Latorre-Pellicer, A., Ascaso, A., Lucía-Campos, C., Gil-Salvador, M., Arnedo, M., Antoñanzas, R., Ayerza-Casas, A., Marcos-Alcalde, I., Gómez-Puertas, P., Ramos, F.J., Pié, J., & Puisac, B. (2021). Things are not always what they seem: From Cornelia de Lange to KBG phenotype in a girl with genetic variants in NIPBL and ANKRD11. Molecular Genetics & Genomic Medicine 9, e1826. [PubMed] [PDF] [https://doi.org/10.1002/mgg3.1826]
128(A).-	Morejón-García, P., Keren, B., Marcos-Alcalde, I., Gómez-Puertas, P., Mochel, F. & Lazo, P.A. (2021). Dysfunctional Homozygous VRK1-D263G variant impairs the assembly of Cajal bodies and DNA damage response in hereditary spastic paraplegia. Neurology Genetics 7, e624. [PubMed] [PDF] [https://doi.org/10.1212/NXG.0000000000000624]
127(A).-	Latorre-Pellicer, A., Gil-Salvador, M., Parenti, I., Lucia-Campos, C., Trujillano, L., Marcos-Alcalde, I., Arnedo, M., Ascaso, A., Ayerza-Casas, A., Antonanzas-Perez, R., Gervasini, C., Piccione, M., Mariani, M., Weber, A., Kanber, D., Kuechler, A., Munteanu, M., Khuller, K., Bueno-Lozano, G., Puisac, B., Gómez-Puertas, P., Selicorni, A., Kaiser, F.J., Ramos, F.J. & Pie, J. (2021). Clinical relevance of postzygotic mosaicism in Cornelia de Lange syndrome and purifying selection of NIPBL variants in blood. Scientific Reports 11, 15459. [PubMed] [PDF] [https://doi.org/10.1038/s41598-021-94958-z]
126(A).-	Rodríguez-Palmero, A., Boerrigter, M.M., Gómez-Andrés, D., Aldinger, K.A., Marcos-Alcalde, I., ... (77 authors) ... Gómez-Puertas, P., Aurora Pujol, A., & Tümer, Z. (2021). DLG4-related synaptopathy: A new rare brain disorder. Genetics in Medicine 23, 888–899. [PubMed] [PDF] [https://doi.org/10.1038/s41436-020-01075-9]
125(A).-	García-Hernández, J.L., Corchete, L.A., Marcos-Alcalde, I., Gómez-Puertas, P., Fons, C. & Lazo, P.A. (2021). Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome. Human Genomics 15, 11. [PubMed] [PDF] [https://doi.org/10.1186/s40246-021-00309-4]

2020:

124(A).-	Lazo, P.A., García, J.L., Gómez-Puertas, P., Marcos-Alcalde, I., Arjona, C., Villarroel, A., González-Sarmiento, R. & Fons, C. (2020). Novel dominant KCNQ2 exon 7 partial in-frame duplication in a complex epileptic and neurodevelopmental delay syndrome. International Journal of Molecular Sciences 21, 4447. [PubMed] [PDF] [https://doi.org/10.3390/ijms21124447]
123(A).-	Marcos, A.T., Martín-Doncel, E., Morejón-García, P., Marcos-Alcalde, I., Gómez-Puertas, P., Segura-Puimedon, M., Armengol, L., Navarro-Pando, J.M. & Lazo, P.A. (2020). VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy. Annals of Clinical and Translational Neurology 7, 808-818. [PubMed] [PDF] [Suppl. Mat. PDF] [https://doi.org/10.1002/acn3.51050]
122(A).-	Ruiz-Márvez, E., Ramírez, C.A., Rodríguez, E.R., Flórez, M.M., Delgado, G., Guzmán, F., Gómez-Puertas, P., Requena, J.M. & Puerta, C.J. (2020). Molecular characterization of Tc964, a novel antigenic protein from Trypanosoma cruzi. International Journal of Molecular Sciences 21, 2432. [PubMed] [PDF] [https://doi.org/10.3390/ijms21072432]
121(A).-	Marcos-Alcalde, I., L-V, E. & Gómez-Puertas, P. (2020). MEPSAnd: Minimum Energy Path Surface Analysis over n-dimensional surfaces. Bioinformatics 36, 956–958. [PubMed] [Free-access article link] [PDF] [https://doi.org/10.1093/bioinformatics/btz649]
120(A).-	Krab, L.C., Marcos-Alcalde, I., Assaf, M., Balasubramanian, M., Andersen, J.B., Pedersen, A-M.B., Cefle, K., Fitzpatrick, D., Gudmundsson, S., Huisman, S., McKee, S., Maas, S.M., Menke, L.A., Mulder, P.A., Martínez, F., Mokry, J., Murch, O.D., Parker, M., Pie, J., Ramos, F., Rieubland, C., Scarano, E., Shinawi, M., Gómez-Puertas, P., Tümer, Z. & Hennekam, R.C. (2020). Delineation of phenotypes related to cohesin structural protein RAD21. Human Genetics 139, 575–592. [PubMed] [PDF] [Suppl. Mat. PDF] [https://doi.org/10.1007/s00439-020-02138-2]
119(A).-	Latorre-Pellicer, A., Ascaso, A., Trujillano, L., Gil-Salvador, M., Arnedo, M., Lucia-Campos, C., Antoñanzas-Pérez, R., Marcos-Alcalde, I., Parenti, I., Bueno-Lozano, G., Musio, A., Puisac, B., Kaiser, F.J., Ramos, F.J., Gómez-Puertas, P. & Pié, J. (Corresponding authors) (2020). Evaluating Face2Gene as a Tool to Identify Cornelia de Lange Syndrome by Facial Phenotypes. International Journal of Molecular Sciences* 21, 1042. [PubMed] [PDF] [https://doi.org/10.3390/ijms21031042]

2019:

118(R).-	Arnedo, M., Latorre-Pellicer, A., Lucia-Campos, C., Gil-Salvador, M., Antoñanzas-Pérez, R., Gómez-Puertas, P., Bueno-Lozano, G., Puisac, B. & Pié, J. (2019). More Than One HMG-CoA Lyase: The Classical Mitochondrial Enzyme Plus the Peroxisomal and the Cytosolic Ones. International Journal of Molecular Sciences 20, 6124. [PubMed] [PDF] [https://doi.org/10.3390/ijms20246124]
117(A).-	Gudmundsson, S., Annéren, G., Marcos-Alcalde, I., Wilbe, M., Melin, M., Gómez-Puertas, P. & Bondeson, M-L. (2019). A novel RAD21 p.(Gln592del) variant expands the clinical description of Cornelia de Lange syndrome type 4 - review of the literature. European Journal of Medical Genetics 62, 103526. [PubMed] [PDF] [https://doi.org/10.1016/j.ejmg.2018.08.007]
116(A).-	Reis, F.P., Bárria, C., Gómez-Puertas, P., Gomes, C.M. & Arraiano, C.M. (2019). Identification of temperature-sensitive mutations and characterization of thermolabile RNase II variants. FEBS Letters, 593, 352-360. [PubMed] [PDF] [https://doi.org/10.1002/1873-3468.13313]

2018:

115(A).-

López-Camacho, E., Paño-Pardo, J.R., Ruiz-Carrascoso, G., Wesselink, J-J., Lusa-Bernal, S., Ramos-Ruiz, R., Ovalle, S., , Gómez-Gila, R., Pérez-Blanco, V., Pérez-Vázquez, M., Gómez-Puertas, P., & Mingorance, J. (2018). Population structure of OXA-48-producing Klebsiella pneumoniae ST405 isolates during a hospital outbreak characterized by genomic typing. Journal of Global Antimicrobial Resistance 15, 48-54. [PubMed] [PDF] [https://doi.org/10.1016/j.jgar.2018.06.008]

114(A).-

*Puisac, B., *Marcos-Alcalde, I., Hernández-Marcos, M., Tobajas, P., Levtova, A., Schwahn, B.C., DeLaet, C., Lace, B., **Gómez-Puertas, P. & **Pié, J. (*Co-first-authors. **Corresponding authors). (2018). Human mitochondrial HMG-CoA synthase deficiency: role of enzyme dimerization surface and characterization of three new patients. International Journal of Molecular Sciences 19, 1010. [PubMed] [PDF] [https://doi.org/10.3390/ijms19041010]

2017:

113(A).-	Marcos-Alcalde, I., Mendieta-Moreno, J.I., Puisac, B., Gil-Rodríguez, M.C., Hernández-Marcos, M., Soler-Polo, D., Ramos, F.J., Ortega, J., Pié, J., Mendieta, J. & Gómez-Puertas, P. (2017). Two-step ATP-driven opening of cohesin head. Scientific Reports 7, 3266. [PubMed] [PDF] [https://doi.org/10.1038/s41598-017-03118-9]
112(A).-	Buey, R.M., Fernández-Justel, D., Marcos-Alcalde. Í., Winter, G., Gómez-Puertas, P., de Pereda, J.M. & Revuelta, J.L. (2017). A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases. Scientific Reports 7, 2648. [PubMed] [PDF] [https://doi.org/10.1038/s41598-017-02805-x]
111(A).-	Puisac, P., Teresa-Rodrigo, M.E., Hernández-Marcos, M., Baquero-Montoya, C., Gil-Rodríguez, M.C., Visnes, T., Bot, C., Gómez-Puertas, P., Kaiser, F.J., Ramos, F.J., Ström, L. & Pié, J. (2017). mRNA quantification of NIPBL isoforms A and B in adult and fetal human tissues, and a pathological variant affecting only isoform A in two patients with Cornelia de Lange Syndrome. International Journal of Molecular Sciences 18, 481. [PubMed] [PDF] [https://doi.org/10.3390/ijms18030481]

2016:

110(A).-	Mendieta-Moreno, J., Trabada, D., Mendieta, J., Lewis, J., Gómez-Puertas, P. & Ortega, J. (2016). Quantum Mechanics / Molecular Mechanics Free Energy Maps and Nonadiabatic Simulations for a Photochemical Reaction in DNA: Cyclobutane Thymine Dimer. Journal of Physical Chemistry Letters 7, 4391–4397. [PubMed] [PDF] [https://doi.org/10.1021/acs.jpclett.6b02168]
109(A).-	Aguilera Rossi, C.A., Gómez-Puertas, P. & Ayala Serrano, J.A. (2016). In vivo functional and molecular characterization of the Penicillin-Binding Protein 4 (DacB) of Pseudomonas aeruginosa. BMC Microbiology 16, 234. [PubMed] [PDF] [https://doi.org/10.1186/s12866-016-0853-x]
108(R).-	Pié, J., Puisac, B., Hernández-Marcos, M., Teresa-Rodrigo, M.E., Gil-Rodríguez, M.C., Baquero-Montoya, C., Bernal, M.L., Bueno, I., Gómez-Puertas, P. & Ramos, F.J. (2016). Special cases in Cornelia de Lange Syndrome: the Spanish experience. American Journal of Medical Genetics Part C 172C, 198-205 [PubMed] [PDF] [https://doi.org/10.1002/ajmg.c.31501]

2015:

107(A).-	Marcos-Alcalde, I., Setoain, J., Mendieta-Moreno, J.I., Mendieta, J. & Gómez-Puertas, P. (2015). MEPSA: minimum energy pathway analysis for energy landscapes. Bioinformatics 31, 3853-3855. [PubMed] [PDF] [https://doi.org/10.1093/bioinformatics/btv453]
106(A).-	Salvarelli, E., Krupka, M., Rivas, G., Mingorance, J., Gómez-Puertas, P., Alfonso, C. & Rico, A.I. (2015). The Cell Division Protein FtsZ from Streptococcus pneumoniae Exhibits a GTPase Activity Delay. Journal of Biological Chemistry 290, 25081–25089. [PubMed] [PDF] [https://doi.org/10.1074/jbc.M115.650077]
105(A).-	Mendieta-Moreno, J.I., Marcos-Alcalde, I., Trabada, D.G., Gómez-Puertas, P., Ortega, J. & Mendieta, J. (2015). A practical Quantum Mechanics Molecular Mechanics method for the dynamical study of reactions in biomolecules. Advances in Protein Chemistry and Structural Biology 100, 67-88. [PubMed] [PDF] [https://doi.org/10.1016/bs.apcsb.2015.06.003]
104(A).-	Valdivieso, E., Perteguer, M.J., Hurtado, C., Campioli, P., Rodríguez, E., Saborido, A., Martínez-Sernández, V., Gómez-Puertas, P., Ubeira, F.M. & Gárate, T. (2015). ANISERP: a new serpin from the parasite Anisakis simplex. Parasites & Vectors 8, 399. [PubMed] [PDF] [https://doi.org/10.1186/s13071-015-1006-z]
103(A).-	Martín-García, F., Papaleo, E., Gómez-Puertas, P., Boomsma, W. & Lindorff-Larsen, K. (2015). Comparing molecular dynamics force fields in the essential subspace. Plos ONE 10, e0121114. [PubMed] [PDF] [https://doi.org/10.1371/journal.pone.0121114]
102(A).-	Gil-Rodríguez, M.C., ... , Marcos-Alcalde, I., Wesselink, J-J., Lusa-Bernal, S., ... , Gómez-Puertas, P., ..., & Pié, J. (2015). De novo Heterozygous Mutations in SMC3 Cause a Range of Cornelia De Lange Syndrome-Overlapping Phenotypes. Human Mutation 36, 454-462. [PubMed] [PDF] [https://doi.org/10.1002/humu.22761]

2014:

101(A).-	Baquero-Montoya, C., Gil-Rodríguez, M.C., Hernández-Marcos, M., Teresa-Rodrigo, M.E., Vicente-Gabas, A., Bernal, M.L., Casale, C.H., Bueno-Lozano, G., Bueno-Martínez, I., Queralt, E., Villa, O., Hernando-Davalillo, C., Armengol, L., Gómez-Puertas, P., Puisac, B., Selicorni, A., Ramos, F.J. & Pié, J. (2014). Severe ipsilateral musculoskeletal involvement in a Cornelia de Lange patient with a novel NIPBL mutation. European Journal of Medical Genetics 57, 503-509. [PubMed] [PDF] [https://doi.org/10.1016/j.ejmg.2014.05.006]
100(A).-	Mendieta-Moreno, J.I., Walker, R., Lewis, J., Gómez-Puertas, P., ^Mendieta, J. & ^Ortega, J. (Corresponding authors; ^Co-last authors) (2014). FIREBALL/AMBER: An efficient local-orbital DFT QM/MM method for biomolecular systems. Journal of Chemical Theory and Computation* 10, 2185–2193. [PDF] [https://doi.org/10.1021/ct500033w]
99(R).-	Iozzo, P., Holmes, M., Schmidt, M.V., Cirulli, F., Guzzardi, M.A., Berry, A., Balsevich, G., Andreassi, M.G., Wesselink J.J., Liistro, T. Gómez-Puertas, P., Eriksson, J.G. & Seckl, J. (2014). Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of Maternal Obesity - Introduction to DORIAN. Obesity Facts 7, 130-151. [PDF] [https://doi.org/10.1159/000362656]
98(A).-	López-Camacho, E., Rentero, Z., Ruiz-Carrascoso, G., Wesselink, J-J., Pérez-Vázquez, M., Lusa-Bernal, S., Gómez-Puertas, P., Kingsley, R.A., Gómez-Sánchez, P., Campos, J., Oteo, J. & Mingorance, J. (2014). Design of clone-specific probes from genome sequences for rapid PCR-typing of outbreak pathogens. Clinical Microbiology and Infection 20, O891-O893. [PubMed] [PDF - manuscript] [https://doi.org/10.1111/1469-0691.12616]
97(A).-	Betancor, G., ,Nevot, M., Mendieta, J., Gómez-Puertas, P., Martínez, M.A. & Menéndez-Arias, L. (2014). Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients. Antiviral Research 106, 42-52. [PubMed] [PDF] [Supplementary Info PDF] [https://doi.org/10.1016/j.antiviral.2014.03.004]
96(A).-	Baquero-Montoya, C., Gil-Rodríguez, M.C., Braunholz D., Teresa-Rodrigo, M.E., Obieglo C., Gener, B., Schwarzmayr, T., Strom, T.M., Gómez-Puertas, P., Puisac, B., Gillessen- Kaesbach, G., Musio, A., Ramos, F.J., Kaiser, F.J. & Pié, J. (2014). Somatic mosaicism in a Cornelia de Lange syndrome patient with NIPBL mutation identified by different Next Generation Sequencing approaches. Clinical Genetics 86, 595–597. [PubMed] [PDF] [https://doi.org/10.1111/cge.12333]
95(A).-	Gonzalez de Prado Salas, P., Hörger, I., Martín-García, F., Mendieta, J., Alonso, A., Encinar, M., Gómez-Puertas, P., Vélez, M. & Tarazona, P. (2014). Torsion and curvature of FtsZ filaments. Soft Matter 10, 1977-1986. [PubMed] [PDF] [Supplementary Info PDF] [https://doi.org/10.1039/c3sm52516c]

2013:

94(A).-	Reis, F.P., Barbas, A., Klauer, A.A., Schaeffer, D., L-V, E., Gómez-Puertas, P., van Hoof, A. & Arraiano, C.M. (2013). Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product. PLoS ONE 8(11): e76504. [PubMed] [PDF] [https://doi.org/10.1371/journal.pone.0076504]
93(A).-	Ramos, M., Menao, S., Arnedo, M., Puisac, B., Gil-Rodríguez, M.C., Teresa-Rodrigo, M.E., Hernández-Marcos, M., Pierre, G., Ramaswami, U., Baquero-Montoya, C., Bueno, G., Casale, C., Hegardt, F.G, Gómez-Puertas, P. & Pié, J. (2013). New case of Mitochondrial HMG-CoA Synthase deficiency. Functional analysis of eight mutations. European Journal of Medical Genetics 56, 411-415. [PubMed] [PDF] [https://doi.org/10.1016/j.ejmg.2013.05.008]
92(A).-	Puisac, B., Teresa-Rodrigo, M.E., Arnedo, M., Gil-Rodríguez, M.C., Pérez-Cerdá, C., Ribes, A., Pié, A., Bueno, G., Gómez-Puertas, P. & Pié, J. (2013). Analysis of aberrant splicing and nonsense-mediated decay of the stop codon mutations c.109G>T and c.504_505delCT in 7 patients with HMG-CoA lyase deficiency. Molecular Genetics and Metabolism 108, 232-240. [PubMed] [PDF] nbsp;[https://doi.org/10.1016/j.ymgme.2013.01.019]
91(A).-	Martín-García, F., Mendieta-Moreno, J.I., Marcos-Alcalde, I, Gómez-Puertas, P. & Mendieta, J. ( Corresponding author). (2013). Simulation of catalytic water activation in mitochondrial F1-ATPase using a hybrid quantum mechanics/molecular mechanics approach: An alternative role for ß-Glu 188. Biochemistry 52, 959-966. [PubMed] [PDF] [Supp. Inf. PDF] [Supp. video. AVI] [https://doi.org/10.1021/bi301109x]
90(A).-	Perteguer, M.J., Gómez-Puertas, P., Cañavate, C., Dagger, F., Gárate, T. & Valdivieso, E. (2013). Ddi1-like protein from Leishmania major is an active Aspartyl-Proteinase. Cell Stress & Chaperones 18, 171–181. [PubMed] [PDF] [Supp. Inf. PDF] [cover paper / artículo de portada] [https://doi.org/10.1007/s12192-012-0368-9]

2012:

89(A).-	Wesselink, J.J., López-Camacho, E., De la Peña, S., Ramos-Ruiz, R., Ruiz-Carrascoso, G., Lusa-Bernal, S., Fernández-Soria, V., Gómez-Gil, R., Gómez-Puertas, P. & Mingorance, J. (* Corresponding authors). (2012). Genome sequence of OXA-48 carbapenemase producing Klebsiella pneumoniae KpO3210. Journal of Bacteriology 194, 6981. [PubMed] [PDF] [https://doi.org/10.1128/JB.01897-12]
88(A).-	Arnedo, M., Menao, S., Puisac, B., Teresa-Rodrigo, M., Gil-Rodríguez, M., L-V, E., Gómez-Puertas, P., Casals, N., Casale, C.H., Hegardt, F.G. & Pie, J. (2012). Characterization of a novel HMG-CoA Lyase enzyme with a dual location in endoplasmic reticulum and cytosol. Journal of Lipid Research 53, 2046-2056. [PubMed] [PDF] [https://doi.org/10.1194/jlr.M025700]
87(A).-	Ahijado-Guzmán, R., Gómez-Puertas, P., Alvarez-Puebla, R.A., Rivas, G. & Liz-Marzán, L.M. (2012). SERS-based detection of the interactions between the essential cell division FtsZ protein and bacterial membrane elements. ACS Nano 6, 7514-7520. [PubMed] [PDF] [https://doi.org/10.1021/nn302825u]
86(A).-	González-Magaldi, M., Postigo, R., de la Torre, B.G., Vieira, Y.A, L-V, E., Gómez-Puertas, P., Andreu, D., Kremer, L., Rosas, M.F. & Sobrino, F. (2012). Mutations that hamper dimerization of foot-and-mouth disease virus 3A protein are detrimental for infectivity. Journal of Virology 86, 11013-11023. [PubMed] [PDF] [https://doi.org/10.1128/JVI.00580-12]
85(A).-	Matos, R.G., L-V, E., Gómez-Puertas, P. & Arraiano, C.M. (2012). The only exoribonuclease present in Haloferax volcanii has an unique response to temperature changes. Biochimica et Biophysica Acta (BBA) - General Subjects 1820, 1543–1552. [PubMed] [PDF] [https://doi.org/10.1016/j.bbagen.2012.06.009]
84(A).-	Martín-García, F., Salvarelli, E., Mendieta-Moreno, J.I., Vicente, M., Mingorance, J., Mendieta, J. & Gómez-Puertas, P. (2012). Molecular dynamics simulation of GTPase activity in polymers of the cell division protein FtsZ. FEBS Letters 586, 1236–1239. [PubMed] [PDF] [Supp. Inf. PDF] [Supp. video. AVI] [Supp. video. MOV -HD-] [https://doi.org/10.1016/j.febslet.2012.03.042]
83(A).-	Martín-García, F., Mendieta-Moreno, J.I., Mendieta, J. & Gómez-Puertas, P. (2012). Molecular dynamics analysis of conformational change of paramyxovirus F protein during the initial steps of membrane fusion. Biochemical and Biophysical Research Communications 420, 42-47. [PubMed] [PDF] [Supp. Inf. PDF] [https://doi.org/10.1016/j.bbrc.2012.02.112]
82(A).-	Martín-García, F., Mendieta-Moreno, J.I., L-V, E., Gómez-Puertas, P. & Mendieta, J. ( Corresponding author) (2012). The Role of Gln(61) in HRas GTP Hydrolysis: A Quantum Mechanics/Molecular Mechanics Study. Biophysical Journal 102, 152-157. [PubMed] [PDF] [Supp. Inf. PDF] [Supp. video. AVI] [Supp. video. AVI -HD-] [https://doi.org/10.1016/j.bpj.2011.11.4005]
81(A).-	Puisac, B., Ramos, M., Arnedo, M., Menao, S., Gil-Rodríguez, M.C., Teresa-Rodrigo, M.E., Pié, A., de Karam, J.C., Wesselink, J.J., Giménez, I., Ramos, F.J., Casals, N., Gómez-Puertas, P., Hegardt, F.G. & Pié, J. (2012). Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway. Molecular Biology Reports 39, 4777-4785. [PubMed] [PDF] [https://doi.org/10.1007/s11033-011-1270-8]

2011:

80(A).-	López, E., Wesselink, J.J., López, I., Mendieta, J., Gómez-Puertas, P. & Muñoz, S.R. (* Co-last authors) (2011). Technical phosphoproteomic and bioinformatic tools useful in cancer research. Journal of Clinical Bioinformatics 1, 26. [PubMed] [PDF]
79(A).-	Matos, R.G., Barbas, A, Gómez-Puertas, P. & Arraiano, C.M. (2011). Swapping the domains of exoribonucleases RNase II and RNase R: conferring upon RNase II the ability to degrade dsRNA. PROTEINS: Structure, Function, and Bioinformatics 79, 1853-1867. [PubMed] [PDF] [Supp. Inf. PDF]
78(A).-	Oroz, J., Valbuena, A., Vera, A.M., Mendieta, J., Gómez-Puertas, P. & Carrión-Vázquez M. (2011). Nanomechanics of the cadherin ectodomain: 'canalization' by Ca2+ binding results in a new mechanical element. Journal of Biological Chemistry 286, 9405-9418. [PubMed] [PDF]
77(R).-	López, E., Matthiesen, R., Mendieta, J., Wesselink, J.J., Gómez-Puertas, P. & Ferreira, A. (2011). Functional phosphoproteomics tools for current immunological disorders research. Journal of Integrated -OMICS 1, 1-16. [Journal] [PDF]
76(A).-	Hurtado, C., Bustos, M.J., Granja, A.G., de León, P., Sabina, P., L-V, E., Gómez-Puertas, P., Revilla, Y. & Carrascosa, A.L. (2011). The African swine fever virus lectin EP153R modulates the surface membrane expression of MHC class I antigens. Archives of Virology 156, 219-234. [PubMed] [PDF]

2010:

75(R).-	Mingorance, J., Rivas, G., Vélez, M., Gómez-Puertas, P. & Vicente, M. (2010). Strong FtsZ is with the force: mechanisms to constrict bacteria. Trends in Microbiology 18, 348-356. [PubMed] [PDF]
74(A).-	Magro, M., Andreu, D., Gómez-Puertas, P., Melero, J.A. & Palomo, C. (2010). Neutralization of Human Respiratory Syncytial Virus Infectivity by Antibodies and Low Molecular Weight Compounds Targeted Against the Fusion (F) Glycoprotein. Journal of Virology 84, 7970-7982. [PubMed] [PDF]
73(R).-	Romanelli, V., Belinchón, A., Benito-Sanz, S., Martínez-Glez, V., Gracia-Bouthelier, R., Heath, K.E., Campos-Barros, A., García-Miñaur, S., Fernández, L., Meneses, H., López-Siguero, J.P., Guillén-Navarro, E., Gómez-Puertas, P., Wesselink, J.J., Mercado, G., Esteban-Marfil, V., Palomo, R., Mena, R., Sánchez, A., del Campo, M. & Lapunzina, P. (2010). CDKN1C (p57Kip2) Analysis in Beckwith-Wiedemann syndrome (BWS) Patients: Genotype-Phenotype Correlations, Novel Mutations, and Polymorphisms. American Journal of Medical Genetics Part A. 152A, 1390-1397. [PubMed] [PDF]
72(A).-	Pié, J., Gil-Rodríguez, M.C., Ciero, M., L-V, E., Ribate, M.P., Arnedo, M., Deardorff, M.A., Puisac, B., Legarreta, J., de Karam, J.C., Rubio, E., Bueno, I., Baldellou, A., Calvo, M.T., Casals, N., Olivares, J.L., Losada, A., Hegardt, F.G., Krantz, I.D., Gómez-Puertas, P. & Ramos F.J. (2010). Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome. American Journal of Medical Genetics. Part A. 152A, 924-929. [PubMed] [PDF] [Suppl.Material. PDF]

2009:

71(A).-	Mendieta, J., Rico, A.I., L-V, E., Vicente, M., Mingorance, J. & Gómez-Puertas, P. (2009). Structural and Functional Model for Ionic (K+/Na+) and pH Dependence of GTPase Activity and Polymerization of FtsZ, the Prokaryotic Ortholog of Tubulin. Journal of Molecular Biology 390, 17-25. [PubMed] [PDF]
70(A).-	Barbas, A., Matos, R.G., Amblar, M., L-V, E., Gómez-Puertas, P. & Arraiano, C.M. (2009). Determination of key residues for catalysis and RNA-cleavage specificity: one mutation turns RNase II into a "super"-enzyme. Journal of Biological Chemistry 284, 20486-20498. [PubMed] [PDF]
69(A).-	Menao, S., L-V, E., Mir, C., Puisac, B., Gratacós, E., Arnedo, M., Carrasco, P., Moreno, S., Ramos, M., Gil, M.C., Pié, A., Ribes, A., Pérez-Cerda, C., Ugarte, M., Clayton, P.T., Korman, S.H., Serra, D., Asins, G., Ramos, F.J., Gómez-Puertas, P., Hegardt, F.G., Casals, N. & Pié, J. (2009). Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria. Human Mutation 30, E520-9. [PubMed] [PDF]
68(A).-	Mera, P., Bentebibel, A., L-V, E., Cordente, A.G., Gurunathan, C., Sebastián, D., Ariza, X., Gómez-Puertas, P., Asins, G., Serra, D., García, J. & Hegardt, F.G. (2009). C75 is Converted to C75-CoA in the Hypothalamus, where it Inhibits Carnitine Palmitoyltransferase 1 and Decreases Food Intake and Body Weight. Biochemical Pharmacology 77, 1084-1095. [PubMed] [PDF]

2008:

67(A).-	Cuellar, J., Martin-Benito, J., Scheres, S.H.W., Sousa, R., Moro, F., L-V, E., Gomez-Puertas, P., Muga, A., Carrascosa, J.L. & Valpuesta, J.M. (2008). The structure of a CCT:Hsc70NBD complex suggests a mechanism for Hsp70 delivery of substrates to the chaperonin. Nature Structural & Molecular Biology 15, 858-864. [PubMed] [PDF] [Suppl.Info-PDF]
66(A).-	Barbas, A., Matos, R.G., Amblar, M., L-V, E., Gómez-Puertas, P. & Arraiano, C.M. (2008). New insights into the mechanism of RNA degradation by ribonuclease II: identification of the residue responsible for setting the RNase II end-product. Journal of Biological Chemistry 283, 13070-13076. [PubMed] [PDF]
65(A).-	Llorente, M.T., Taylor, I.A., L-V, E., Gómez-Puertas, P., Calder, L.J., García-Barreno, B. & Melero, J.A. (2008). Structural properties of the human respiratory syncytial virus P protein: Evidence for an elongated homotetrameric molecule that is the smallest orthologue within the family of paramyxovirus polymerase co-factors. PROTEINS: Structure, Function and Bioinformatics 72, 946-958. [PubMed] [PDF]
64(A).-	Asenjo, A., Mendieta, J., Gómez-Puertas, P. & Villanueva, N. (2008). Residues in human Respiratory syncytial virus P protein that are essential for its activity on RNA viral synthesis. Virus Research 132, 160-173. [PubMed] [PDF]
63(A).-	L-V, E., Atrian, S., Gomez-Puertas, P., Chabás, A., Vilageliu, L. & Grinberg, D. (2008). An evolutionary and structure-based docking model for glucocerebrosidase-saposin C and glucocerebrosidase-substrate interactions. Relevance for Gaucher disease. PROTEINS: Structure, Function and Bioinformatics 70, 882-891. [PubMed] [PDF] ( Co-first authors)*

2007:

62(R).-
Pié J., L-V, E., Puisac, B., Menao, S., Pié A., Casale, C., Ramos, F., Hegardt, F.G., Gómez-Puertas, P. & Casals, N. (2007). Molecular genetics of HMG-CoA lyase deficiency. Molecular Genetics and Metabolism 92, 198-209. [PubMed] [PDF]

61(A).-
L-V, E., Bentebibel, A., Gurunathan, C., Morillas, M., De Arriaga, D., Serra, D., Asins, G., Hegardt, F. & Gómez-Puertas, P. (2007). Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A. Journal of Biological Chemistry 282, 18212-18224. [PubMed] [PDF]

60(A).-
Carrasco, P., Menao, S., L-V, E., Santpere, G., Clotet, J., Sierra, A.Y., Gratacos, E., Puisac, B., Gomez-Puertas, P., Hegardt, F.G., Pie, J. & Casals, N. (2007). C-Terminal End and Aminoacid Lys48 in HMG-Coa Lyase Are Involved in Substrate Binding and Enzyme Activity. Molecular Genetics and Metabolism 91, 120-127. [PubMed] [PDF] (cover paper / artículo de portada).

59(A).- Agirrezabala, X., Velázquez-Muriel, J.A., Gomez-Puertas, P., Scheres, S.H.W., Carazo, J.M., & Carrascosa, J.L. (2007). Quasi-Atomic Model of Bacteriophage T7 Procapsid Shell: Insights into the Structure and Evolution of a Basic Fold. Structure 15, 461-472. [PubMed] [PDF]

58(A).- Cava, F., Laptenko, O., Borukhov, S., Chahlafi, Z., Blas-Galindo, E., Gomez-Puertas, P., & Berenguer, J. (2007). Control of the Respiratory Metabolism of Thermus thermophilus by the Conjugative Respiration Element NCE. Molecular Microbiology 64, 630-646. [PubMed] [PDF]

57(A).-
Contreras, L., Gomez-Puertas, P., Iijima, M., Kobayashi, K., Saheki, T., & Satrústegui, J. (2007). Ca2+ Activation Kinetics of the Two Aspartate-glutamate Mitochondrial Carriers Aralar and Citrin: Role in Heart Malate-aspartate NADH Shuttle. Journal of Biological Chemistry 282, 7098-7106. [PubMed] [PDF]

56(A).- Amblar, M., Barbas, A., Gomez-Puertas, P., & Arraiano, C. (2007). The role of the S1 domain in Exoribonucleolytic Activity: Substrate Specificity and Multimerization. RNA 13, 317-327. [PubMed] [PDF]

55(A).- Martin-Benito, J., Gomez-Reino, J., Stirling, P.C., Lundin, V.F., Gomez-Puertas, P., Boskovic, J., Chacon, P., Fernandez, J.J., Berenguer, J., Leroux, M.R. & Valpuesta, J.M. (2007). Divergent substrate-binding mechanisms reveal an evolutionary specialization of eukaryotic prefoldin compared to its archaeal counterpart. Structure 15, 101-110. [PubMed] [PDF] (cover paper / artículo de portada).

2006:

54(A).- Rodriguez-Pombo, P., Navarrete, R., Merinero, B., Gomez-Puertas, P. & Ugarte, M. (2006). Mutational Spectrum of Maple Syrup Urine Disease in Spain. Human Mutation 27, 715. [PubMed] [PDF]

53(A).-
Cordente, A.G., L-V, E., Vazquez, M.I., Gomez-Puertas, P., Asins, G., Serra, D. & Hegardt, F.G. (2006). Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase. Biochemistry45,6133-6141. [PubMed] [PDF]

52(A).-
Bentebibel, A., Sebastian, D., Herrero, L., L-V, E., Serra, D., Asins, G., Gomez-Puertas, P. & Hegardt, F.G. (2006). Novel effect of C75 on Carnitine Palmitoyltransferase I activity and palmitate oxidation. Biochemistry 45, 4339-4350. [PubMed] [PDF]

51(A).-
Mir, C., L-V, E., Aledo, R., Puisac, B., Rizzo, C., Dionisi-Vici, C., Deodato, F., Pie, J., Gomez-Puertas, P., Hegardt, F.G. & Casals, N. (2006). A single residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase -Review. Journal of Inherited Metabolic Disease 29, 64-70. [PubMed] [PDF]

50(R).-
Ortiz, A.R., Gomez-Puertas, P., Leo-Macias, A., Lopez-Romero, P., L-V, E., Morreale, A., Murcia, M., & Wang, K. (2006) Computational approaches to model ligand selectivity in drug design. Current Topics in Medicinal Chemistry 6, 41-55. [PubMed] [PDF]

2005:

49(R).-
Perez, B., Desviat, L.R., Gomez-Puertas, P., Martinez, A., Stevens, R.C. & Ugarte, M. (2005). Kinetic and stability analysis of PKU mutations identified in BH(4)-responsive patients - Review. Molecular Genetics and Metabolism 86, S11-S16. [PubMed] [PDF]

48(O).-
L-V, E. & Gomez-Puertas, P. (2005) -Scientific divulgation-. Bioinformatica, la informacion al servicio de la ciencia (Bioinformatics, information in the service of science). Journal of the Official College of Physicists of Spain: Fisica y Sociedad 16, 46-50. [PDF]

47(A).-
Tress, M., de Juan, D., Graña, O., Gomez, M.J., Gomez-Puertas, P., Gonzalez, J.M., Lopez, G. & Valencia, A. (2005). Scoring docking models with evolutionary information. PROTEINS: Structure, Function, and Bioinformatics 60, 275-280. [PubMed] [PDF]

46(A).-
Puisac, B., L-V, E., Moreno, S., Mir, C., Perez-Cerda, C., Menao, S., Lluch, D., Pie, A., Gomez-Puertas, P., Casals, N., Ugarte, M., Hegardt, F.G. & Pie, J. (2005). Skipping of exon 2 and exon 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)8 TIM barrel model of HL. Biophysical Chemistry 115, 241-245. [PubMed] [PDF]

2004:

45(A).-
Cordente, A.G., L-V, E., Vazquez, M.I., Swiegers, J.H., Pretorius, I.S., Gomez-Puertas, P., Hegardt, F.G., Asins, G. & Serra, D. (2004). Redesign of carnitine acetyltransferase specificity by protein engineering. Modification of methionine564 broadens the specificity to longer acyl-CoAs as substrates. Journal of Biological Chemistry 279, 33899-33908. [PubMed] [PDF]

44(C).-
L-V, E. & Gomez-Puertas, P. (2004). Sequence and structural alignments of eukaryotic and procaryotic cytoskeletal proteins. Chapter for "Molecules in time and space: Bacterial shape, division and phylogeny." M. Vicente, J. Tamames, A. Valencia & J. Mingorance (Eds.) Kluwer Academic/Plenum Publishers.

43(C).-
Mingorance, J., Rico, A. & Gomez-Puertas, P. (2004). Bacterial morphogenes. Chapter for "Molecules in time and space: Bacterial shape, division and phylogeny." M. Vicente, J. Tamames, A. Valencia & J. Mingorance (Eds.) Kluwer Academic/Plenum Publishers.

42(A).-
Gil, J., García, M.A., Gomez-Puertas, P., Guerra, S., Rullas, J., Nakano, H., Alcami, A. & Esteban, M. (2004). TRAF family proteins link PKR with NF-kB activation. Molecular and Cellular Biology 24, 4502-4512. [PubMed] [PDF]

41(A).-
Morillas, M., L-V, E., Valencia, A., Serra, D., Gomez-Puertas, P., Hegardt, F.G. & Asins, G. (2004). Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal. Biochemical Journal 379, 777-784. [PubMed] [PDF]

40(R).-
Gomez-Puertas, P., Martin-Benito, J., Carrascosa, J.L., Willison, K.R. & Valpuesta, J.M. (2004). The substrate recognition mechanisms in chaperonins - Review. Journal of Molecular Recognition 17, 85-94. [PubMed] [PDF]

39(A).-
Falcon, A.M., Marion, R.M., Zurcher, T., Gomez-Puertas, P., Portela, A., Nieto, A. & Ortin, J. (2004). Defective RNA replication and late gene expression in temperature-sensitive (A/Victoria/3/75) Influenza viruses expressing deleted forms of NS1 protein. Journal of Virology 78, 3880-3888. [PubMed] [PDF]

38(C).-
Lopez-Romero, P., Gomez, M.J., Gomez-Puertas, P. & Valencia, A. (2004). Prediction of functional sites in proteins by evolutionary methods. Chapter for "Principles and Practice. Methods in Proteome and Protein Analysis". R.M. Kamp, J. Calvete & T. Choli-Papadopoulou (Eds.) Springer-Verlag, Berlin Heidelberg.

2003:

37(A).-
Sanchez-Torres, C., Gomez-Puertas, P., Gomez-del-Moral, M., Alonso, F., Escribano, J.M, Ezquerra, A., & Dominguez, J. (2003). Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection. Archives of Virology 148, 2307-2323. [PubMed] [PDF]

36(C).-
Gomez-Puertas, P. & Valencia, A. (2003). Prediccion de estructura de proteinas. Chapter for "Estructura de proteinas". C. Gomez-Moreno & J. Sancho (Eds.) Ariel, Barcelona.

35(C).-
Gomez-Puertas, P. & Valencia, A. (2003). Practica IV: Prediccion de estructura de proteinas. Chapter for "Estructura de proteinas". C. Gomez-Moreno & J. Sancho, (Eds.) Ariel, Barcelona.

34(A).-
Gonzalez, J.M., Gomez-Puertas, P., Cavanagh, D., Gorbalenya, A.E. & Enjuanes, L. (2003). A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae. Archives of Virology 148, 2207-2235. [PubMed] [PDF]

33(A).-
Casals, N., Gomez-Puertas, P., Pie, J., Mir, C., Roca, R., Puisac, B., Aledo, R., Clotet, J., Menao, S., Serra, D., Asins, G., Till, J., Elias-Jones, A.C., Cresto, J.C., Chamoles, N.A., Abdenur, J.E., Mayatepek, E., Besley, G., Valencia, A. &. Hegardt, F.G. (2003). Structural (ab)8 TIM barrel model of 3-hydroxy-3-methylglutaryl coenzyme A lyase. Mutation of Ser75, Ser201 and Asp204 impairs the catalytic activity. Journal of Biological Chemistry 278, 29016-29023. [PubMed] [PDF]

32(O).-
Gomez-Puertas, P. & Valencia, A. (2003). ESF programme on 'Integrated Approaches for Functional Genomics' workshop on 'Modeling of Molecular Networks'. Comparative and Functional Genomics 4, 144-147. [PubMed] [PDF]

31(A).-
Morillas, M., Gomez-Puertas, P., Bentebibel, A., Selles, E., Casals, N., Valencia, A., Hegardt, F.G., Asins, G., & Serra, D. (2003). Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition. Journal of Biological Chemistry 278, 9058-9063. [PubMed] [PDF]

30(A).-
Carettoni, D., Gomez-Puertas, P., Yim, L., Mingorance, J., Massida, O., Vicente, M., Valencia, A., Domenici, E., & Anderluzzi, D. (2003). Phage-display and correlated mutations identify an essential region of subdomain 1C involved in homodimerization of Escherichia coli FtsA. PROTEINS: Structure, Function and Genetics 50, 192-206. [PubMed] [PDF]

2002:

29(A).-
Martin-Benito, J., Boskovic, J., Gomez-Puertas, P., Carrascosa, J.L., Simons, C., Lewis, S.A., Bartolini, F., Cowan, N.J., & Valpuesta, J.M. (2002). Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT. EMBO Journal 21, 6377-6386. [PubMed] [PDF]

28(R).-
Valpuesta, J. M., Martin-Benito, J., Gomez-Puertas, P., Carrascosa, J. L., & Willison, K. R. (2002). Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT - Review. FEBS Letters 529, 11-16. [PubMed] [PDF]

27(A).-
Morillas, M., Gomez-Puertas, P., Rubi, B., Clotet, J., Ariño, J., Valencia, V. , Hegardt, F.G., Serra, D., & Asins, G. (2002). Structural model of a Malonyl-CoA binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I. Mutational analysis of a malonyl-CoA affinity domain. Journal of Biological Chemistry 277, 11473-11480. [PubMed] [PDF]

2001:

26(A).-
Morillas, M., Gomez-Puertas, P., Roca, R., Serra, D., Asins, G., Valencia, V. & Hegardt, F.G. (2001). Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase. Journal of Biological Chemistry 276, 45001-45008. [PubMed] [PDF]

25(A).-
Barderas, M.G., Rodriguez, F., Gomez-Puertas, P., Aviles, M., Beitia, F., Alonso, C. & Escribano J.M. (2001). Antigenic and immunogenic properties of a chimera of two immunodominant African swine fever virus proteins. Archives of Virology 146, 1681-1691. [PubMed] [PDF]

24(A).-
Llorca, O., Martin-Benito, J., Gomez-Puertas, P., Ritco_Vonsovici, M., Willison, K. R., Carrascosa, J. L. & Valpuesta, J. M. (2001). Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin. Journal of Structural Biology 135, 205-218. [PubMed] [PDF]

23(A).-
Mingorance, J., Rueda, S., Gomez-Puertas, P., Valencia, A. & Vicente, M. (2001). Escherichia coli FtsZ polymers contain mostly GTP and have a high nucleotide turnover. Molecular Microbiology 41, 83-91. [PubMed] [PDF]

22(A).-
Bullido, R., Gomez-Puertas, P., Saiz, M.J. & Portela, A. (2001). Influenza A virus NEP (NS2 protein) downregulates RNA synthesis of model template RNAs. Journal of Virology 75, 4912-4917. [PubMed] [PDF]

1991 - 2000:

21(A).-
Gomez-Puertas, P., Albo, C., Perez-Pastrana, E., Vivo, A. & Portela, A. (2000). Influenza virus matrix protein is the major driving force in virus budding. Journal of Virology 74, 11538-11547. [PubMed] [PDF]

20(A).-
Gomez-Puertas, P., Leahy, M.B., Nuttall, P.A. & Portela, A. (2000). Rescue of synthetic RNAs into Thogoto and influenza A virus particles using core proteins purified from Thogoto virus. Virus Research 67, 41-48. [PubMed] [PDF]

19(A).-
Bullido, R., Gomez-Puertas, P., Albo, C. & Portela, A. (2000). Several protein regions contribute to determine the nuclear and cytoplasmic localization of the influenza A virus nucleoprotein. Journal of General Virology 81, 135 - 142. [PubMed] [PDF]

18(A).-
Gomez-Puertas, P., Mena, I., Castillo, M., Vivo, A., Perez-Pastrana, E. & Portela, A. (1999). Efficient formation of influenza virus-like particles: dependence on the expression levels of viral proteins. Journal of General Virology 80, 1635 - 1645. [PubMed] [PDF] (cover paper / artículo de portada)

17(A).-
Fabregas, J., Garcia, D., Fernandez-Alonso, M., Rocha, A.I., Gomez-Puertas, P., Escribano, J.M., Otero, A. & Coll, J.M. (1999). In vitro inhibition of the replication of haemorrhagic septicaemia virus (VHSV) and African swine fever virus (ASFV) by extracts from marine microalgae. Antiviral Research 44, 67 - 73. [PubMed] [PDF]

16(A).-
Gomez-Puertas, P., Rodriguez, F., Oviedo, J.M., Brun, A., Alonso, C. & Escribano, J.M. (1998). The African swine fever virus proteins p54 and p30 are involved in two distinct steps of virus attachment and both contribute to the antibody-mediated protective immune response. Virology 243, 461-471. [PubMed] [PDF]

15(A).-
Oviedo, J.M., Rodriguez, F., Gomez-Puertas, P., Brun, A., Gomez, N. & Escribano, J.M. (1997). High level expression of the major antigenic African swine fever virus proteins p54 and p30 in baculovirus and their potential use as diagnostic reagents. Journal of Virological Methods 64, 27-35. [PubMed] [PDF]

14(A).-
Gomez-Puertas, P., Oviedo, J.M., Rodriguez, F., Coll., J. & Escribano, J.M. (1997). Neutralization susceptibility of African swine fever virus is dependent on the phospholipid composition of viral particles. Virology 228, 180-189. [PubMed] [PDF]

13(A).-
Gomez-Puertas, P. & Escribano, J.M. (1997). Blocking antibodies inhibit complete African swine fever virus neutralization. Virus Research 49, 115-122. [PubMed] [PDF]

12(A).-
Rodriguez, F., Ley, V., Gomez-Puertas, P., Garcia, R., Rodriguez, J.F. & Escribano, J.M. (1996). The structural protein p54 is essential for African swine fever virus viability. Virus Research 40, 161-167. [PubMed] [PDF]

11(A).-
Gomez-Puertas, P., Rodriguez, F., Oviedo, J.M., Ramiro-Ibañez, F., Ruiz-Gonzalvo, F., Alonso, C. & Escribano, J.M. (1996). Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization. Journal of Virology 70, 5689-5694. [PubMed] [PDF]

10(A).-
Gomez-Puertas, P., Rodriguez, F., Ortega, A., Oviedo, J.M., Alonso, C. & Escribano, J.M. (1995). Improvement of African swine fever virus neutralization assay using recombinant viruses expressing chromogenic marker genes. Journal of Virological Methods 55, 271-279. [PubMed] [PDF]

9(A).-
Blanco, P., Huidrobro, A., Villalba, M., Gomez-Puertas, P., Villa, A., Bogonez, E., Martinez-Serrano, A., Aparicio, J.J. & Satrustegui, J. (1994). The activity of synaptosomal calcium channels is inversely correlated with working memory performance in memory impaired, aged rats. Neuroscience Letters 165, 5-8. [PubMed]

8(A).-
Villalba, M., Martinez-Serrano, A., Gomez-Puertas, P., Blanco, P., Borner, C., Villa, A., Casado, M., Gimenez, C., Pereira, R., Bogonez, E., Pozzan, T. & Satrustegui, J. (1994). The role of pyruvate in neuronal calcium homeostasis: effects on intracellular calcium pools. Journal of Biological Chemistry 269 (4), 2468-2476. [PubMed] [PDF]

7(A).-
Gomez-Puertas, P., Satrustegui, J. & Bogonez, E. (1994). Synaptic vesicles isolated from 32P-prelabeled synaptosomes contain a phosphoprotein of apparent Mr. 65,000 (pp65), a possible substrate for PKC. Journal of Biological Chemistry 269 (10), 7564-7570. [PubMed] [PDF]

6(C).-
Satrustegui, J., Martinez-Serrano, A., Blanco, P., Villalba, M., Gomez-Puertas, P. & Bogonez, E. (1993). Altered calcium homeostasis during ageing of the brain: cellular mechanisms involved and possible consecuences. Chapter for "Model Systems: Neuroregulatory Mechanisms in Ageing." M.H. Makman & G.B. Stefano (Eds.) Pergamon Press.Ltd. (Oxford).

5(C).-
Satrustegui, J., Blanco, P., Villalba, M., Pereira, R., Börner, C., Gomez-Puertas, P., Villa, A., Bogonez, E. & Martinez-Serrano, A. (1993). Calcium binding to the cytosol and regulation of cytosolic free calcium levels in presynaptic nerve endings from different brain regions and their alterations with ageing. Chapter for "Aspects of Aging and Disease." D.L. Knook & G. Hofecker (Eds.) Facultas Verlag, Vienna.

4(A).-
Huidrobro, A., Blanco, P., Villalba, M., Gomez-Puertas, P., Villa, A., Bogonez, E., Martinez-Serrano, A., Aparicio, J.J. & Satrustegui, J. (1993). Age-related changes in calcium homeostatic mechanisms in synaptosomes in relation with working memory deficiency. Neurobiology of Aging 14, 479-486. [PubMed]

3(A).-
Bogonez, E., Gomez-Puertas, P. & Satrustegui, J. (1992). Pyruvate Dehydrogenase Dephosphorylation in rat brain synaptosomes and mitochondria: evidence for a calcium-mediated effect in response to depolarization, and variation due to ageing. Neuroscience Letters 142, 123-127. [PubMed]

2(C).-
Satrustegui, J., Bogonez, E., Villalba, M., Blanco, P., Pereira, R., Gomez-Puertas, P., Villa, A., Börner, C. & Martinez-Serrano, A. (1992). Calcium and ageing. Chapter for "Ca antagonists and neurological disorders." J. Garcia de Yebenes (Ed.) Marcel Dekker, Inc., New York.

1(A).-
Gomez-Puertas, P., Martinez-Serrano, A., Blanco, P., Satrustegui, J. & Bogonez, E. (1991). Conditions restricting depolarization-dependent calcium influx in synaptosomes reveal a graded response of P96 dephosphorylation and a transient dephosphorylation of P65. Journal of Neurochemistry 56, 2039-2047. [PubMed]

Meetings / Congresos

12th Biennial Meeting of the International Society for Neurochemistry. 1989. El Algarve (Portugal).
I Congreso Iberoamericano de Biofísica. 1989. Sevilla. (Spain).
XVI Congreso Nacional de la Sociedad Española de Bioquímica. 1989. Alicante. (Spain).
8th General Meeting of the European Society for Neurochemistry. 1990. Leipzig (Germany).
Simposio Multidisciplinario sobre Enfermedad de Alzheimer y Otras Demencias. 1990. Pamplona. (Spain).
IV Portuguese-Spanish Biochemistry Congress. 1991. Póvoa de Varzim (Portugal).
8th International Conference on Second Messengers & Phosphoproteins. 1992. Glasgow (Scotland).
II Congreso Iberoamericano de Geriatría y Gerontología - V Centenario. 1992. Sevilla. (Spain).
V Congreso Nacional de Virología. 1995. Madrid. (Spain).
The First European Meeting of Virology. 1995. Würzburg (Germany).
IX International Meeting on Poxvirus and Iridovirus. 1996. Toledo. (Spain).
IV Congreso Nacional de Virología. 1997. Santiago de Compostela. (Spain).
XIth International Congress of Virology. 1999. Sydney (Australia).
VI Congreso Nacional de Virología. 1999. Madrid (Spain).
European Virology 2000. Glasgow (Scotland).
Chaperonins: Structure and Function. 2000. Juan March Inst. Madrid (Spain).
Structural Genomics and Bioinformatics. 2001. Juan March Inst. Madrid (Spain).
XXIV Congreso de la SEBBM. 2001. Spain.
Manufacturing Bacteria: Cell Division Components. 2002. Juan March Inst. Madrid (Spain).
(Invited / Invitado) Blue Sky Workshop. US-EC TaskForce on Biotechnology Research. 2001. Washington D.C. (USA).
(Chairman / Moderador) III Jornadas de Bioinformática. 2002. Salamanca (Spain).
(Organizer / Organizador) ESF Workshop: Modeling of molecular networks. 2002. Granada (Spain).
(Invited / Invitado) ESF Workshop: Protein Structure Prediction. 2002. Antalya (Turkey).
(Invited / Invitado) Mundo BIOTECH 2003. Madrid (Spain).
(Committee member / Miembro del Comité) IV Jornadas de Bioinformática JBI 2003. La Coruña (Spain).
BIFI 2004. Biology after the Genome: a Physical View. Zaragoza (Spain).
Micro_MATRIX workshop on Antimicrobial Resistance. 2004. Las Navas (Spain).
(Invited / Invitado) Mundo BIOTECH 2004. Madrid (Spain).
V Jornadas de Bioinformática. 2004. Barcelona (Spain).
(Invited / Invitado) I Jornadas Divinocell. 2006. Madrid. (Spain).
IX Congreso Nacional de Virología. 2007. Zaragoza. (Spain).
6th International Respiratory Syncytial Virus Symposium. 2007. Marco Island, Florida (USA).
32nd FEBS Congress: Molecular Machines. 2007. Wien (Austria).
(Scientific Committee / Comité Científico) 1st International Workshop on Bioinformatic and Chemoinformatic Intelligent Systems. 2007. Salamanca. (Spain).
(Invited / Invitado) I workshop "Cornelia de Lange Syndrome and Cohesinopaties". 2007. Zaragoza. (Spain).
(Chairman / Moderador) 1st International Symposium CIBERobn. 2007. Santiago de Compostela. (Spain).
XXIX Congreso Chileno de Microbiología. 2008. Viña del Mar (Chile).
(Scientific Committee / Comité Científico) 8th Spanish Symposium on Bioinformatics and Computational Biology. 2008. Valencia. (Spain).
(Scientific Committee / Comité Científico) 2nd International Workshop on Practical Applications of Computational Biology & Bioinformatics (IWPACBB'08). 2008. Salamanca. (Spain).
(Invited / Invitado) 1st International Divinocell Meeting. 2009. Las Rozas - Madrid. (Spain).
XXXII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. 2009. Oviedo. (Spain).
Frontiers of Prokaryotic Cell Biology. EMBO workshop. 2009. Oxford (UK)
(Invited / Invitado) 2nd International Divinocell Meeting. 2010. Cambridge. (UK).
(Invited / Invitado) Workshop in Biomathematics. Institute for the Mathematical Sciences. 2010. Madrid (Spain).
(Closing conference / Conferencia de clausura) 1st Physiology Workshop. Faculty of Medicine. University of Zaragoza. 2010. Zaragoza (Spain).
(Invited / Invitado) XXXIII Congreso Sociedad Española de Bioquímica y Biología Molecular. 2010. Córdoba (Spain).
IV Spanish-Portuguese Biophysical Congress. 2010. Zaragoza (Spain).
(Chairman / Moderador) Bioinformatics Solutions. BIOSPAIN 2010 - 5th International Meeting on Biotechnology. 2010. Pamplona (Spain).
(Scientific Committee / Comité Científico) Xth Spanish Symposium on Bioinformatics (JBI2010). 2010. Málaga (Spain).
(Invited / Invitado) COMBACT closing workshop. 2010. Madrid (Spain).
(Scientific Committee / Comité Científico) 5th International Conference on Practical Applications of Computational Biology & Bioinformatics (IWPACBB’11) 2011. Salamanca. (Spain).
(Invited / Invitado) ESF Exploratory Workshop - PESC. Bacterial Protein Dynamic Scaffolds For Fabrication Of Self-organized Nanostructures. 2011. Madrid (Spain).
(Invited / Invitado) 2nd Meeting of Madrid Synthetic Biology Club. CNB-CSIC. 2011. Madrid (Spain).
(Invited / Invitado) Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA-CSIC) 2011. Salamanca (Spain).
8th European Biophysics Congres. 2011 Budapest (Hungary).
XIth Spanish Simposium on Bioinformatics (JBI2012). 2012. Barcelona (Spain).
(Invited / Invitado) DORIAN workshop. Epigenetics and Obesity. 2012. Pisa (Italy).
(Invited / Invitado) EMBO workshop "Reconstructing the essential bacterial cell cycle machinery". 2012. La Granja - Segovia (Spain).
(Invited / Invitado) EU COST action "CODECS 2013 WORKSHOP - COnvergent Distributed Environment for Computational Spectroscopy" 2013. El Escorial. Madrid (Spain).
(Invited / Invitado) Meeting of Computational Biology Groups at the Autonomous University of Madrid. COMP-BIOL @ UAM 2013. Cantoblanco, Madrid (Spain).
(Invited / Invitado) Division From A to Z. CNB Workshop 2013. Cantoblanco, Madrid (Spain).
(Invited / Invitado) DORIAN workshop. Epigenetics and Obesity. 2014. Madrid (Spain).
(Invited / Invitado) Bioscience and Big data. Big Data Week. 2014. Madrid (Spain).
(Invited / Invitado) Cumbre Atlántica de Promoción de la Salud y Educación para la Salud. 2015. Madrid (Spain).
(Invited / Invitado) X National Meeting "Cornelia de Lange Syndrome" AESCL. 2015. Madrid (Spain).
(Invited / Invitado) Global ImasT - Transferencia de Tecnología. 2015. Madrid (Spain).
(Invited / Invitado) Ciencia en primera persona. Museo Nacional de Ciencia y Tecnología. 2017 Madrid (Spain).
(Invited / Invitado) IBM POWER9 meeting. 2018 Valencia (Spain).
(Invited / Invitado) XI CIBERER meeting. 2018. Castelldefels, Barcelona (Spain).
(Invited / Invitado) I Reunión de Bioinformáica y Biología Computacional de la Comunidad de Madrid. 2018.
(Invited / Invitado) XIV National Meeting "Cornelia de Lange Syndrome" AESCL. 2019. Madrid (Spain).
(Invited / Invitado) IBM Call for Code 2020 Global Challenge Webcast. 2020. Madrid (Spain).
(Invited / Invitado) ERN ITHACA - WG7 Research Meeting. 2021 Copenhagen (Denmark).
(Invited / Invitado) XII Congreso de Fisiología. 2022. University of Zaragoza (Spain).
(Invited / Invitado) Session PROA-HULP. 2022. La Paz University Hospital, Madrid (Spain).
(Invited / Invitado) 2nd Congress "Conexión Cáncer - CSIC". 2023. Benidorm (Spain).
(Invited / Invitado) XII World Congress "Cornelia de Lange Syndrome". 2023. Zaragoza (Spain).
(Invited / Invitado) II Workshop on innovative approaches in Sarcoma: Drug development in Sarcoma. 2023. Madrid (Spain).
(Invited / Invitado) XI International Conference BIFI. Artificial Intelligence at the Crossroads of Interdisciplinary Science. 2024. Zaragoza (Spain).

TEACHING / DOCENCIA

Thesis direction / Dirección de tesis doctorales:

Jose Maria Oviedo Valencia. "Propiedades antigénicas e inmunogénicas de las proteínas mayoritarias p72, p30 y p54 del virus de la Peste porcina africana". Cum laude. Universidad Complutense de Madrid. 1997.
ELV. "Integración de información evolutiva y estructural mediante herramientas bioinformáticas. Estudio funcional de la familia de enzimas de las carnitina/colina-aciltransferasas."Cum laude. Universidad Autónoma de Madrid. 2008.
Fernando Martín García. "Análisis mediante Dinámica Molecular y Mecánica Cuántica / Mecánica Molecular de la Reacciones de Hidrólisis en Proteínas NTPasas."/ "Molecular Dynamics and Quantum Mechanics / Molecular Mechanics Analysis of Hydrolysis Reactions in NTPase Proteins." Cum laude. Universidad Autónoma de Madrid. 2013.
Jesús Ignacio Mendieta Moreno. "Simulación de reacciones en biomoléculas con QM/MM." / "QM/MM simulation of reactions in biomolecules." (Cum laude). Universidad Autónoma de Madrid. 2017
Íñigo Marcos Alcalde. "Computational modeling of cohesin ATPase dynamics." (Cum laude). Universidad Autónoma de Madrid. 2018

Advanced Studies Diploma / Diploma de Estudios Avanzados:

ELV. Universidad Autónoma de Madrid. 2004.

Master Diploma:

Fernando Martín García. Master in Biophysics. Universidad Autónoma de Madrid. 2010.
Jesús Ignacio Mendieta Moreno. Master in Biophysics. Universidad Autónoma de Madrid. 2011.
Íñigo Marcos Alcalde. Master in Biophysics. Universidad Autónoma de Madrid. 2011.

Science outreach / Divulgación científica:

COMBACT extension: COMBACT conferences for secondary school students / Conferencias COMBACT para estudiantes de secundaria. 2007-2010.

IES Benjamin Rua (Móstoles, Madrid). Mar-2008.
IES Leon Felipe (Getafe, Madrid). May-2008.
IES Los Rosales (Móstoles, Madrid). Nov-2008.
IES Los Castillos (Alcorcón, Madrid). Feb-2009.
IES Leon Felipe (Getafe, Madrid). May-2009.
Colegio Virgen de Europa (Boadilla, Madrid). Feb-2010.
Colegio Fuenllana (Alcorcón, Madrid). Feb-2010.
IES Francisco Umbral (Ciempozuelos, Madrid). Dic-2010.

Colegio Altair (Madrid). Mar-2011.
IES Senda Galiana (Torres de la Alameda, Madrid). Mar-2011.
IES Leon Felipe (Getafe, Madrid). Jun-2011.
IES Los Castillos (Alcorcón, Madrid). Dic-2011.
IES Leon Felipe (Getafe, Madrid). Jun-2012.
IES Leon Felipe (Getafe, Madrid). May-2013.
IES Los Castillos (Alcorcón, Madrid). Abr-2014.
IES Los Castillos (Alcorcón, Madrid). Abr-2016.
IES Arquitecto Pedro Gumiel (Alcalá de Henares, Madrid). Feb. 2019.
IES Los Castillos (Alcorcón, Madrid). Mar. 2019.
Colegio Nazaret - Oporto (Madrid). Nov. 2019.
IES Cardenal Cisneros (Alcalá de Henares, Madrid). Feb. 2020.
CEIPSO Príncipe don Felipe (Boadilla del Monte, Madrid). Oct. 2022.
IES Las Musas (Madrid). Oct. 2022.
Colegio Nuevo Equipo (Madrid). Oct. 2022.

Museo Nacional de Ciencia y Tecnología MUNCYT. Science in the First Person: Understanding My Genome. 11-Jun-2017.
[PDF]
"Popular science book “CIENCIA, y yo quiero ser científico!!!" 03-Abr-2018. https://cienciayyoquierosercientifico.blogspot.com.es/
"Popular science magazine "QUO". Generation DNA. Dec-2018.
"Participation in the "Catalogue of CSIC Scientific Conferences for the Community of Madrid 2018-2020 & 2021-2023".

Undergraduate courses / Asignaturas de licenciatura:

Farmacology and Molecular Toxicology. Biochemistry. Universidad Autónoma de Madrid (2005-2006).
Farmacology and Molecular Toxicology. Biochemistry. Universidad Autónoma de Madrid (2006-2007).
Farmacology and Molecular Toxicology. Biochemistry. Universidad Autónoma de Madrid (2007-2008).

Posgraduate courses / Cursos de doctorado y especialización:

Bioinformatics Course on Gene Identification and Protein Functional Analysis. "Instituto Gulbenkian de Ciência". Oeiras, Portugal (2000).
Ph. D. Course on Bioinformatics. "BioInfo2001". Faculty of Sciences. Universidad Autónoma de Madrid. Spain. (2001).
Text queries: SRS, Entrez. "Bioinformatics: Use of genetic databases in plant breeding". International Centre for Advanced Mediterranean Agronomic Studies. Zaragoza (2001).
"Bioinformatics". Ph.D. course. Microbiology area. Universidad de Leon. Spain (2001).
Doctorado: Eines informàtiques per a Genètica Molecular. Universidad de Barcelona (2001).
Specialist in Bioinformatics: Genomics and Proteomics. Fundacion General de la Universidad Complutense. Madrid (2001).
Ph. D. Course on Bioinformatics. "BioInfo2002". Faculty of Sciences. Universidad Autónoma de Madrid. Spain. (2002).
I3P course: Protein modeling. Centro Nacional de Biotecnologia. Madrid (2002).
Ph.D. Course: Eines informàtiques per a Genètica Molecular. Universitat de Barcelona (2002).
Integrative Bioinformatics. "Introduction to Bioinformatics". Universidad de Salamanca (2002).
Sequence alignment. Motifs, profiles and domains. "Theoretical and Practical course on Bioinformatics". ALMA Bioinformatica. Madrid. (2002).
Bioinformatics: DNA analysis. Universidad de Leon (2002).
Prediction of protein structure and function. Cursos de Verano de El Escorial (2002).
Specialist in Bioinformatics: Genomics and Proteomics. Fundacion General de la Universidad Complutense. Madrid (2002).
Bioinformatics: Protein analysis. Universidad de Leon (2002).
Analysis and Comparison of Genes and Genomes. VI Master Biotecnology. Univ. Autónoma de Madrid (2002).
Ph. D. Course on Bioinformatics. "BioInfo2003". Faculty of Sciences. Universidad Autónoma de Madrid. Spain. (2003).
Ph. D. Course on Bioinformatics: Analysis of Genomes and Proteins Structure. Universidad de Leon. Spain. (2003).
Master in Bioinformatics and Computational biology. Coordinator. Universidad Complutense de Madrid (2003).
Ph.D. Course: Eines informàtiques per a Genètica Molecular. Universitat de Barcelona (2003).
II Theoretical and Practical course on Bioinformatics. ALMA Bioinformatica. Madrid (2003).
SemBioGen 2003. Seminar: Bioinformatics for Genetics. Universidad de Zaragoza (2003).
Specialist in Bioinformatics: Genomics and Proteomics. Fundacion General de la Universidad Complutense. Madrid (2003).
Predicción de estructuras e interaciones entre proteínas. JBI-2003. La Coruña (2003).
Protein Structure and Function. EuroLab course: Advanced Computing in NMR Spectroscopy. Florencia, Italia. (2003).
Ph. D. Course on Bioinformatics. "BioInfo2004". Faculty of Sciences. Universidad Autónoma de Madrid. Spain. (2004).
Ph. D. Course on Bioinformatics: Analysis of Gene Sequence and Expression Data. Universidad de Leon. Spain. (2004).
Analisis de datos de expresion genica. DNA arrays. Centro de Biologia Molecular Severo Ochoa. Madrid (2004).
Ph.D. course: Eines informàtiques per a Genètica Molecular. Universitat de Barcelona (2004).
Doctorado: Predicción de estructura de proteínas. Centro Nacional de Investigaciones Oncológicas. Madrid (2004).
Prediction of Protein structure.Homology modeling. Centro de Biología Molecular Severo Ochoa. Madrid (2004).
Bioinformatica y Biologia Computacional. Escuela Complutense de Verano. Madrid (2004).
Ph. D. Course: Bioinformática: análisis y predicción de secuencia y estructura de proteínas. Universidad Autónoma de Madrid (2005).
Ph. D. Course: Análisis bioinformático de secuencias y expresión de genes y genomas. Universidad Autónoma de Madrid (2005).
Alineamiento de secuencias y modelado de proteínas. Centro de Biologia Molecular Severo Ochoa. Madrid (2005).
Bioinformática: Introduccion a la predicción de estructura de proteínas e interacciones proteína-ligando. Universidad de León. Spain (2005).
Bioinformática. Análisis y predicción de estructura de proteínas. Nodo50. Madrid (2005).
Bioinformática. Dto. Farmacología y Fisiología. Facultad de Medicina. Universidad de Zaragoza (2005).
Bioinformática. Curso: Genómica y Proteómica. Hospital Gregorio Marañón. Madrid (2005).
Análisis de secuencias y estructura de proteínas. Centro Nacional de Investigaciones Oncológicas CNIO. Madrid (2005).
Anotación de secuencias de genes. Bases de datos. Gene Ontology. INBIOTEC - Universidad de León. Spain (2005).
Eines per a l'anàlisi de seqüències i estructures de proteïnes. Universitat de Barcelona (2005).
Bioinformática: Genómica y Proteómica. Escuela Complutense de Verano. Univ. Complutense de Madrid (2005).
Ph. D. Course: Bioinformática: análisis y predicción de secuencia y estructura de proteínas. Universidad Autónoma de Madrid (2006).
Biotecnología y Bioinformática. Universidad de León. Spain (2006).
Estructura de proteínas: modelos teóricos. Centro Nacional de Investigaciones Oncológicas CNIO. Madrid (2006).
Bioinformática. Estructura y función de proteínas. Facultad de Medicina. Universidad de Zaragoza (2006).
Eines per a l'anàlisi de seqüències i estructures de proteïnes. Universitat de Barcelona (2006).
Ph. D. Course: Bioinformática: análisis y predicción de secuencia y estructura de proteínas. Universidad Autónoma de Madrid (2007).
Biotecnología y Bioinformática. Universidad de León. Spain (2007).
Bioinformática. Estructura y función de proteínas. Universidad de Zaragoza (2007).
Eines per a l'anàlisi de seqüències i estructures de proteïnes. Universitat de Barcelona (2007).
Bioinformática. Análisis computacional de secuencia y estructura de proteínas como herramientas para el diseño de fármacos. UAM (2007).
Curso básico de Bioinformática. BIOMOL-INFORMATICS SL. Madrid (2007).
Bioinformática. Master en Biofísica de la Universidad Autónoma de Madrid, 2007-2008.
Ph. D. Course: Bioinformática: análisis y predicción de secuencia y estructura de proteínas. Universidad Autónoma de Madrid (2008).
Biotecnología y Bioinformática. Universidad de León. Spain (2008).
Bioinformática. Estructura y función de proteínas. Universidad de Zaragoza (2008).
Master de Recerça Basica en Odontologia i Biomedicina. Universitat Internacional de Catalunya. Barcelona (2008).
Introducción al Diseño Molecular 3D de Proteínas. Instituto de Salud Carlos III (2009).
II-Master de Recerça Basica en Odontologia i Biomedicina. Universitat Internacional de Catalunya. Barcelona (2009).
Bioinformática. Estructura y función de proteínas. Universidad de Zaragoza (2009).
Genómica aplicada a la Medicina Clínica (Bioinformática y Biomedicina). Institut Català de Ciències Cardiovasculars (ICCC), Barcelona (2009).
Genómica aplicada a la Medicina Clínica (Bioinformática y Biomedicina). Hospital Universitario Ramón y Cajal, Madrid (2009).
Master en Investigacion Biomédica Traslacional. Universidad de Córdoba (2010).
Genómica aplicada a la Medicina Clínica (Bioinformática y Biomedicina). Hospital Universitario La Paz, Madrid (2010).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2011).
Diseño Molecular 3D de Proteínas. Instituto de Salud Carlos III (2011).
Fundamentos de Bioinformática. Centro de Investigacion y Tecnologia Agroalimentaria. CITA - DGA. Zaragoza (2012).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2012).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2013).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2014).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2015).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2016).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2017).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2018).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2019).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2020).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2021).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2022).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2023).
Bioinformática. Master en Virología. Universidad Complutense de Madrid (2024).